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KMID : 1007320070130020106
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Journal of the Korean Society of Menopause
2007 Volume.13 No. 2 p.106 ~ p.113
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Association of LRP5 Gene Polymorphisms with Bone Mineral Density in Postmenopausal Korean Women
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Kwon Dong-Jin
Han Chan-Hee
Kim Jin-Hong
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Abstract
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Objectives: To evaluate the association of LRP5 gene polymorphisms with bone mineral density (BMD) in postmenopausal Korean women.
Methods: The LRP5 gene polymorphisms were analyzed by restriction fragment length polymorphism (RFLP) in 229 postmenopausal Korean. The BMD was checked using dual-energy x-ray absorptiometer (DEXA) at lumar spine, femur neck, Ward’s triangle, and greater trochanter of femur, and women in the study were classified into 3 gorups (normal, osteopenia and osteroporosis) according to their BMD.
Results: The frequency of genotype C/C of C1677A was significantly high in osteoporosis group, and that of C/A was much low in osteoporosis group. The frequency of genotype T/C of T2268C was high in osteoporosis group, while that of C/C was low in the same group. There was no significant relationship between LRP5 polymorphisms and BMD.
Conclusion: The LRP5 gene polymorphisms were not associated with the BMD
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KEYWORD
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LRP5, Polymorphism, Osteoporosis
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